METHOD OF PRODUCING SODIUM SALT OF 6-[3-(2-CHLORO-6-FLUOROPHENYL)-5-METHYLISOXAZOLE-4-CARBAMINO]-PENICILLANIC ACID Russian patent published in 2012 - IPC C07D499/12 C07D499/16 C07D499/76 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing a sodium salt of 6-[3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbamino]-penicillanic acid (flucloxacillin). The method is realised by simultaneously feeding into an aqueous solution of a sodium salt 6-aminopenicillanic acid, acetone solution of acid chloride of 3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic acid and aqueous solution of sodium hydroxide while keeping pH of the medium at 6.5-9.0. The formed sodium salt of flucloxacillin is extracted after preliminary removal of acetone and is carried out by feeding a saturated solution of sodium chloride or acetate into the reaction mass.

EFFECT: improved method of producing a sodium salt of 6-[3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carbamino]-penicillanic acid.

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