FIELD: medicine. SUBSTANCE: sodium salt of penicillanic acid is used as reagent 1. Chloride of 3-phenyl-5-methylisoxasol-4-carboxylic acid is used as reagent 2. Reaction is carried out in aqueous alkali medium at pH 6.5-9.0, temperature being 6-15 C. The process takes place in the presence of acetone or copolymer of styrene and divinylbenzene or mixture of water with nonpolar solvent. Optical density of 0.5 solution of desired product at 335 nm is 0.01, its yield being 97.9 EFFECT: improves efficiency of the method.
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| METHOD OF PREPARING CEPHALOSPORIN C ZINC SALT | 1985 |
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| METHOD FOR PRODUCTION OF AMPICILLLIN | 1993 |
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| 0 |
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SU527138A3 |
