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2 457 837

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IPC

A61K31/205(2006-01-01)

A61K33/30(2006-01-01)

A61P37/00(2006-01-01)

A61P43/00(2006-01-01)

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Application

2011129505/15, 2011-07-15

(24)

Start date

2011-07-15

(22)

Actual filing date

2011-07-15

(45)

Published

2012-08-10

(72)

Inventor

Rasulov Maksud MukhamedzhanovichZvereva Marina ValentinovnaNurbekov Malik KubanychbekovichAdamovich Sergej NikolaevichMirskova Anna NikolaevnaMirskov Rudol'F Grigor'EvichVoronkov Mikhail Grigor'Evich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauki Irkutskij Institut Khimii Im. A.E. Favorskogo Sibirskogo Otdelenija Rossijskoj Akademii Nauk

COMPLEX OF TRIS-(2-HYDROXYETHYL)AMINE WITH ZINK BIS-(2-METHYLPHENOXYACETATE), INCREASING CYTOKIN ACTIVITY OF TOTAL TRIPTOPHANYL-tRNA-SYNTHETASE Russian patent published in 2012 - IPC A61K31/205 A61K33/30 A61P37/00 A61P43/00

Abstract RU 2457837 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed is application of complex of tris-(2-hydroxyethyl)amine with zink bis-(2-methylphenoxyacetate) [cresoxyzinkatrane] of formula (HOCH₂CH₂)₃N·Zn(OOCCH₂OC₆H₄CH₃-2)₂ as stimulator of cytokine activity of total triptophanyl-tRNK synthetase. Demonstrated is increase of total triptophanyl-tRNK synthetase by 50% in comparison with control in dose 5 mg/kg with intramuscular introduction during 2 months; introduction of cresoxyzinkatrane in the same dose but together (simultaneously) with cholesterol during 3 months also produces expressed effect - increase of TRSase level.

EFFECT: invention can be used in medicine and biology as basis for creation of medications of anti-sclerosis action, for instance, for prevention of sclerotic affection of blood vessels.

1 dwg

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RU 2 457 837 C1

Authors

Rasulov Maksud Mukhamedzhanovich

Zvereva Marina Valentinovna

Nurbekov Malik Kubanychbekovich

Adamovich Sergej Nikolaevich

Mirskova Anna Nikolaevna

Mirskov Rudol'F Grigor'Evich

Voronkov Mikhail Grigor'Evich

Dates

2012-08-10—Published

2011-07-15—Filed