NOVEL 2-AMINOOXAZOLINES AS TAAR1 LIGANDS Russian patent published in 2012 - IPC C07D263/28 C07D413/06 C07D413/14 A61K31/421 A61K31/422 A61K31/4427 A61K31/4709 A61K31/506 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention is a 6-10-member aryl selected from phenyl, naphthyl, tetrahydronaphthalenyl, indanyl or a 6-member heteroaryl containing 1-2 N atoms, selected from pyridyl or pyrimidinyl, where the aryl and heteroaryl groups can be unsubstituted or substituted with 1-3 substitutes selected from a group consisting of C_3-6-cycloalkyl, phenyl, phenyloxy, benzyl, benzyloxy, halogen atom, C_1-7-alkyl, C_1-7-alkoxy, oxazolyl, piperidin-1-yl, or C_1-7-alkyl, substituted with a halogen atom, or represents phenyl, where at least one hydrogen atom is substituted with deuterium or tritium; R² is a hydrogen atom, C_1-7-alkyl or is benzyl, unsubstituted or substituted C_1-7-alkoxy or halogen atom; or R¹ and R² together with a N atom with which they are bonded form 2,3-dihydroindol-1-yl or 3,4-dihydro-1quinolin-1-yl. The invention also relates to a method of producing compounds of formula and to a pharmaceutical composition having high affinity for the TAAR1 receptor.

EFFECT: compounds of formula (I), having high affinity for the TAAR1 receptor.

29 cl, 4 dwg, 1 tbl, 183 ex