SIONERGISTIC PHARMACEUTICAL COMBINATION FOR PAIN TREATMENT (VERSIONS) Russian patent published in 2012 - IPC A61K31/137 A61K31/167 A61P25/02

Abstract RU 2463042 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed are: application of combination of flurpirtine and tramadol or their physiologically acceptable salts with weight ratio of flurpirtine to tramadol from 10:1 to 1:14 for pain treatment and application of the same combination for obtaining mediaction for peroral, rectal, intravenous, transcutaneous, or subcutaneous or intracutaneous introduction for pain treatment.

EFFECT: demonstrated is increased efficiency (synergism) of combination in pain treatment and unexpected "anti-vomiting" effect of flurpirtine in combination with vomiting-inducing high dose of tramadol; as well as introduction of combination results in reduction of such side effects as cramps, increased muscle tone and vomiting.

13 cl, 6 tbl

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RU 2 463 042 C2

Authors

Zelenyj Ishtvan

Knota Peter Jorgen

Maus Ioakhim

Dates

2012-10-10—Published

2004-12-09—Filed