FIELD: medicine.
SUBSTANCE: invention describes a method for stabilising a sensitive ingredient for biological absorption in the oral intake in a therapeutic composition involving the stages of combining pregelatinised starch with at least one sensitive ingredient, and mixing the sensitive ingredient with pregelatinised starch. Pregelatinised starch is used in the amount of 5% to 80% of composition weight. The sensitive ingredient is specified in vitamin C, phenylephrine and their combinations. The sensitive ingredient is used in the amount of 0.1% to 20% of composition weight. Said sensitive ingredient is uniformly distributed in pregelatinised starch and adsorbed on pregelatinised starch.
EFFECT: stability of said sensitive ingredients and maintenance of their activity and availability for biological absorption in the oral intake of the therapeutic composition.
17 cl, 15 ex
Title | Year | Author | Number |
---|---|---|---|
COMPOSITIONS AND METHODS OF ACTIVE PHARMACEUTICAL INGREDIENT STABILISATION | 2005 |
|
RU2391115C2 |
QUICKLY DECOMPOSING, PRESSED IN FORMS MATERIALS AND METHOD OF THEIR PREPARING | 1997 |
|
RU2189227C2 |
PHARMACEUTICAL COMPOSITION FOR COMBINATION OF PIPERIDINE ALKANOL WITH ANTIEDEMIC AGENT | 1998 |
|
RU2207879C2 |
DOSAGE FORM OF ORALLY DISINTEGRATING TWO-PIECE TABLET | 2008 |
|
RU2466719C2 |
SOLID DOSED OUT FORM OF SIMETHICON FOR PERORAL APPLICATION | 2002 |
|
RU2362569C2 |
COMPOSITION CONTAINING PARACETAMOL AND GLUTATHIONE, AND METHOD FOR ITS OBTAINING | 2012 |
|
RU2620340C2 |
NEW DOSAGE FORM | 2006 |
|
RU2431473C2 |
FILM-COATED SOLID DOSAGE FORM COMPRISING HONEY IN THE COATING | 2012 |
|
RU2605299C2 |
PHARMACEUTICAL COMPOSITIONS COMPRISING INHIBITOR OF HMG-REDUCTASE | 2000 |
|
RU2206324C1 |
PHARMACEUTICAL PREPARATIONS WITH FIXED COMBINATION OF ANALGESIC AND ANTISPASMODIC AGENTS DOSES | 2015 |
|
RU2704613C2 |
Authors
Dates
2012-11-20—Published
2008-09-24—Filed