FIELD: organic chemistry, medicine, biochemistry, pharmacy. SUBSTANCE: invention relates to pharmaceutical composition comprising (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2- [methyl(methylsulfonyl)amino]pyrimidine-5-yl]-(3R, 5S)-3,5-dihydroxyhept-6-enoic acid as an inhibitor of HMG CoA-reductase or its pharmaceutically acceptable salt as an active component. Composition comprises also tribasic phosphate salt where cation is multivalent one. Tribasic phosphate salt represents preferably tribasic calcium phosphate. Composition retains stability for prolonged time. EFFECT: valuable properties of composition. 21 cl, 4 ex
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Year |
Author |
Number |
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2000 |
- Krikmor Dzhozef Richard
- Vidzhins Norman Alfred
|
RU2264210C2 |
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2013 |
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|
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| PHRAMACEUTICAL COMPOSITIONS CONTAINING ZD6474 |
2005 |
|
RU2383343C2 |
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2000 |
- Kehmeron Norman Judzhin
- Kotter Mehri Ehnn
|
RU2239456C2 |
| CRYSTALLINE HYDRATED FORM OF BIS-[(E)-7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[METHYL(METHYLSULFONYL)AMINO]-PYRIMIDINE-5-YL]-(3R,5S)-3,5-DIHYDROXYHEPT-6-ENOIC ACID] CALCIUM SALT, METHOD FOR ITS PREPARING, PHARMACEUTICAL COMPOSITION, METHOD FOR ITS PREPARING AND METHOD FOR TREATMENT |
1999 |
|
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2015 |
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- Ganeeva Gulnaz Shamilevna
|
RU2606592C1 |
| APPLICATION OF ROSUVASTATIN (ZD-4522) IN TREATING HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA |
2001 |
- Rehjza Ali
- Khatchinson Khauard Dzherard
|
RU2294744C2 |
| PHARMACEUTICAL COMPOSITION CONTAINING ALEGLITEZAR |
2010 |
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- Paul' Vojtera
|
RU2537224C2 |
| PERORAL PHARMACEUTICAL MEDICINAL FORMS INCLUDING PROTON PUMP INHIBITOR AND ANTACID SUBSTANCE OR ALGINATE |
1996 |
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- Khal'Gren Agneta
|
RU2179453C2 |
| TWO-LAYER TABLET COMPOSITION |
2020 |
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- Patel, Dzhatin, M.
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- Timmins, Piter
|
RU2824129C2 |
