FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed is application of combination of (a) 13,14-dihydro-15-keta-16,16-dihalogen-derivative of prostaglandin, represented by formula 
(II) and (b) inhibitor of H+, K+-ATPase, which represents compound of general formula 
(II) in combination with pharmaceutically acceptable excipient for manufacturing pharmaceutical composition (demonstrating synergistic effect in treatment of gastrointestinal disorders), for treatment of gastrointestinal diseases and corresponding treatment method and synergistic pharmaceutical composition of the same purpose.
EFFECT: demonstrated is synergism of combination of 13,14-dihydro-15-keto-16,16-difluoroprostaglandin E1 in combination with omeprazole or lansoprazole in reduction of gastric ulcer dimensions.
15 cl, 1 dwg, 5 tbl, 5 ex
