2-(PIPERIDIN-4-YL)-4-PHENOXY- OR PHENYLAMINOPYRIMIDINE DERIVATIVES AS NON NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS Russian patent published in 2012 - IPC C07D403/12 C07D403/14 C07D401/14 C07D471/10 A61K31/506 A61P31/18 

FIELD: chemistry.

SUBSTANCE: present invention refers to compounds of formula I or their pharmaceutically acceptable salts showing activity with respect to HIV reverse transcriptase, as well as to a based pharmaceutical composition (I). In formula I R¹ means phenyl(C₁-C₃)alkyl, heteroaryl(C₁-C₃)alkyl, phenyl or heteroaryl optionally substituted by one-three substitutes independently specified in groups (a)-(r), R² means -CN, -CH=CHCN or halogen; R³ means hydrogen, halogen, amino group, halogen(C₁-C₆)alkyl, -CN or methyl; R⁴ means hydrogen, Br or amino group; R^5a and R^5b independently mean hydrogen, C₁-C₆alkyl, C₁-C₆alkoxy group or halogen; R^6a and R^6b either independently mean hydrogen, or together mean ethylene; X means NH or O. The groups (a)-(r) are such as presented in the patent claim.

EFFECT: preparing pharmaceutically acceptable salts possessing activity with respect to HIV reverse transcriptase.

17 cl, 42 ex, 6 dwg, 5 tbl