Patenton — panteon of patents

(19)

RU

(11)

2 604 062

(13)

C2

(51)

IPC

C07D487/04(2006-01-01)

C07D495/04(2006-01-01)

A61K31/519(2006-01-01)

A61K31/4365(2006-01-01)

A61P29/00(2006-01-01)

A61P11/06(2006-01-01)

(21) (22)

Application

2013103539/04, 2011-07-08

(24)

Start date

2011-07-08

(22)

Actual filing date

2011-07-08

(45)

Published

2016-12-10

(72)

Inventor

Arora NidkhiChen ShaotsinGermann Jokhannes KorneliusKuglstatter AndreasLabadi Sharada ShenviLin Klara Jeu JenLukas Metju K.Mor Emi DzheraldinPapp EvaTalamas Fransisko KsaverVanner JuttaChzhaj Tszanshen

(73)

Holder

F.Hoffmann-La Roche Ag

PYRAZOLO[1,5-a]PYRIMIDINE AND THIENO[3,2-b]PYRIMIDINE DERIVATIVES AS MODULATORS OF IRAK-4 Russian patent published in 2016 - IPC C07D487/04 C07D495/04 A61K31/519 A61K31/4365 A61P29/00 A61P11/06 

Abstract RU 2604062 C2

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula Ia or IIa, where R1, R3 and R4 have the values specified in the patent claim. Invention also relates to a composition for treating inflammatory or autoimmune state and use of compounds of formulae Ia or IIa in preparing a medicine for treating an inflammatory disorder or an autoimmune disorder.

EFFECT: compounds, which are the subject of the invention, are effective for treating states associated with interleukin-1 receptor-associated kinase (IRAK), particularly IRAK-1 and/or IRAK-4.

9 cl, 1 tbl, 52 of preparatory ex, 31 ex

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RU 2 604 062 C2

Authors

Arora Nidkhi

Chen Shaotsin

Germann Jokhannes Kornelius

Kuglstatter Andreas

Labadi Sharada Shenvi

Lin Klara Jeu Jen

Lukas Metju K.

Mor Emi Dzheraldin

Papp Eva

Talamas Fransisko Ksaver

Vanner Jutta

Chzhaj Tszanshen

Dates

2016-12-10—Published

2011-07-08—Filed

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