ORGANIC COMPOUNDS Russian patent published in 2013 - IPC A61K31/135 A61K31/661 A61K31/436 A61K38/21 A61P25/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: group of inventions relates to medicine and deals with pharmaceutical combination of receptor S1P agonist with accompanying agent for treatment of demyelinating diseases except optic nerve neuritis. In claimed pharmaceutical combination agonist of S1P receptor is 2-amino-2-[2-(4-octylphenyl)ethyl]pronane-1,3-diol (FTY720) in free form, in form of pharmaceutically acceptable salt or (FTY720) phosphate, and accompanying agent is interferon, in particular interferon β, or mTOR inhibitor, in particular rapamycin, 40-O-(2-hydroxyethyl)rapamycin or other rapamycin derivative. Claimed is method of treatment, relief or delay of progress of demyelinating disease except optic nerve neuritis, in particular of disseminated sclerosis and Guillain-Barre syndrome, which includes introduction of said combination. Also claimed is application of said combination for manufacturing respective medication.

EFFECT: group of inventions ensures increase of therapy of demyelinating diseases due to synergistic action of combination components.

11 cl