DERIVATIVES OF 4-AMINOPYRIMIDINE Russian patent published in 2013 - IPC C07D403/04 C07D239/48 A61K31/397 A61K31/40 A61K31/506 A61P29/00 A61P37/00 

FIELD: biotechnologies.

SUBSTANCE: invention relates to new derivatives of 4-aminopyrimidine, having antagonistic activity in respect to the receptor H₄. In the formula : R₁ is selected from C_1-8alkyl, C_3-8cycloalkyl-C_0-6alkyl, aryl-C_1-6alkyl, the group of the formula R₂ and R₃ together with the atom N, with which they are linked, creating the saturated heterocyclic group, which may be a 4-7-member monocyclic or 9-member condensed bycyclic one, where the specified heterocyclic group may contain up to two atoms N and does not contain any other heteroatoms, and may be unnecessarily substituted with one or more substitutes, independently selected from C_1-4alkyl and NR_aR_b, provided that if the heterocyclic group either contains 2 atoms N and is not substituted with the group NR_aR_b, or comprises 1 atom N and is substituted with one group NR_aR_b; or R₂ is H, and R₃ is pyrrolidinyl substituted with C_1-4alkyl group; where R_a is H or C_1-4alkyl; R_b is H or C_1-4alkyl; R₄ and R₅ is H; R₆ is aryl group; n is equal to 1; and aryl is phenyl group, unnecessarily substituted with halogen. The invention also relates to a pharmaceutical composition containing the specified compounds, to application of compounds for production of a medicinal agent for treatment of such diseases as an allergic, immunological or inflammatory diseases or pain, and also to a method for production of the specified compounds.

EFFECT: higher efficiency of application of compounds in treatment of diseases.

34 cl, 30 ex