FIELD: biotechnologies.
SUBSTANCE: invention relates to new derivatives of 4-aminopyrimidine, having antagonistic activity in respect to the receptor H4. In the formula : R1 is selected from C1-8alkyl, C3-8cycloalkyl-C0-6alkyl, aryl-C1-6alkyl, the group of the formula
R2 and R3 together with the atom N, with which they are linked, creating the saturated heterocyclic group, which may be a 4-7-member monocyclic or 9-member condensed bycyclic one, where the specified heterocyclic group may contain up to two atoms N and does not contain any other heteroatoms, and may be unnecessarily substituted with one or more substitutes, independently selected from C1-4alkyl and NRaRb, provided that if the heterocyclic group either contains 2 atoms N and is not substituted with the group NRaRb, or comprises 1 atom N and is substituted with one group NRaRb; or R2 is H, and R3 is pyrrolidinyl substituted with C1-4alkyl group; where Ra is H or C1-4alkyl; Rb is H or C1-4alkyl; R4 and R5 is H; R6 is aryl group; n is equal to 1; and aryl is phenyl group, unnecessarily substituted with halogen. The invention also relates to a pharmaceutical composition containing the specified compounds, to application of compounds for production of a medicinal agent for treatment of such diseases as an allergic, immunological or inflammatory diseases or pain, and also to a method for production of the specified compounds.
EFFECT: higher efficiency of application of compounds in treatment of diseases.
34 cl, 30 ex
Title | Year | Author | Number |
---|---|---|---|
BETA-LACTAMASE INHIBITORS | 2009 |
|
RU2445314C9 |
AMINOALKYLPYRIMIDINE DERIVATIVES AS HISTAMINE H RECEPTOR ANTAGONISTS | 2010 |
|
RU2573828C2 |
IMIDAZOPYRIDINE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | 2009 |
|
RU2518089C2 |
THERAPEUTICALLY ACTIVE DERIVATIVES OF OXAZOLINE | 2013 |
|
RU2656209C2 |
NOVEL PYRIMIDINE DERIVATIVES AND THEIR APPLICATION IN THERAPY, AS WELL AS APPLICATION OF PYRIMIDINE DERIVATIVES IN MANUFACTURING MEDICATION FOR PREVENTION AND/OR TREATMENT OF ALZHEIMER'S DISEASE | 2006 |
|
RU2433128C2 |
3,7-DIAZABICYCLO[3.3.0]OCTANES AND THEIR USING IN TREATMENT OF CARDIAC ARRHYTHMIA | 2002 |
|
RU2293085C2 |
MONOMER DERIVATIVES OF GLYCOPEPTIDE ANTIBIOTIC | 2005 |
|
RU2424248C2 |
SUBSTITUTED QUINAZINE DERIVATIVES AS FGFR-KINASE INHIBITORS FOR TREATMENT OF CANCER | 2011 |
|
RU2602233C2 |
QUINAZOLINONE DERIVATIVES APPLICABLE AS MODULATORS OF FGFR KINASE | 2014 |
|
RU2701517C2 |
ANTHELMINTHIC DEPSIPEPTIDE COMPOUNDS | 2016 |
|
RU2715556C2 |
Authors
Dates
2013-08-10—Published
2008-12-18—Filed