IMIDAZOPYRIDINE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES Russian patent published in 2014 - IPC C07D471/04 C07D513/04 A61K31/437 A61K31/506 A61K31/4545 A61K31/501 A61K31/53 A61K31/444 A61K31/497 A61K31/496 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel derivatives of bicyclic heterocyclic compounds of formula (I), which can be applied in prevention or treatment of abnormal or pathological condition, mediated by FGFR kinase, such as cancer. In formula compound, (i) in case when R¹ and R² independently represent hydrogen or C_3-8cycloalkyl; A is group A^a, which represents aromatic group, representing phenyl; R³ represents hydrogen or C_1-6alkyl; R⁴ represents group R^4a, which represents amino, halogen, C_1-6alkyl, -X-R⁵, phenyl or aromatic heterocyclic group, where said heterocyclic group represents 5- or 6-membered heterocyclyl group and contains 1, 2 or 3 heteroatoms, independently selected from nitrogen, oxygen or sulphur, where said phenyl or said heterocyclyl group can be optionally substituted with one or two R^b groups; or (ii) when R¹ represents hydrogen and R² represents C_1-6alkyl or halogenC_1-6alkyl; A is group A^b, which represents aromatic 5-membered heterocyclic group; R³ represents hydrogen or C_1-6alkyl; R⁴ is group R^4a, which represents halogen; or (iii) when R¹ represents hydrogen and R² represents C_1-6alkyl or halogenC_1-6alkyl; A is group A^c, which represents aromatic 6-membered heterocyclic group, containing one nitrogen atom as heteroatom; R³ represents hydrogen or C_1-6alkyl; R⁴ is group R^4b, which represents halogen, C_1-6alkyl, -X-R⁵ or aromatic heterocyclic group, containing 1, 2 or 3 heteroatoms, independently selected from nitrogen, oxygen and sulphur. Other values of radicals are given in the invention formula.

EFFECT: obtaining novel derivatives of bicyclic heterocyclic compounds.

21 cl, 7 tbl, 250 ex