ELEMENT BOUND WITH INTERLEUKIN-4 RECEPTOR α (IL-4Rα)-173 Russian patent published in 2013 - IPC C07K16/28 

FIELD: chemistry.

SUBSTANCE: invention relates to biochemistry and discloses an isolated antibody which specifically binds a human interleukin-4 receptor α (hlL-4Ra). The antibody includes a VH antibody domain which contains a set of CDR: HCDR1, HCDR2, HCDR3 and a framework region, and a VL antibody domain containing a set of CDR: LCDR1, LCDR2 and LCDR3 and a framework region, wherein the set of CDR has 10 or less substitutions of amino acids selected from the set of CDR, where: HCDR1 is characterised by amino acid sequence SEQ ID NO:193; HCDR2 is characterised by amino acid sequence SEQ ID NO:194; HCDR3 is characterised by amino acid sequence SEQ ID NO:195; LCDR1 is characterised by amino acid sequence SEQ ID NO:198; LCDR2 is characterised by amino acid sequence SEQ ID NO:199; and LCDR3 is characterised by amino acid sequence SEQ ID NO:200, and where the substitutions do not result in loss of the capability to bind hIL-4Ra.

EFFECT: invention broadens the range of antibodies that specifically bind interleukin-4 receptor α.

15 cl, 17 dwg, 7 tbl, 5 ex