TYPE 1 DIACYLGLYCEROL O-ACYLTRANSFERASE ENZYME INHIBITORS Russian patent published in 2013 - IPC C07D277/20 C07D401/04 C07D401/12 C07D401/14 C07D417/04 C07D417/12 C07D417/14 C07D493/08 A61K31/427 A61K31/44 A61P3/04 A61P3/10 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a compound of formula or a pharmaceutically acceptable salt thereof, wherein G¹ is phenyl or pyridyl, each of which is optionally additionally substituted by one substitute presented by T; G² is phenyl, 1,3-thiazolyl or 1,3-oxazolyl, wherein G² is bound to G¹ in the para position in relation to a place of attachment of G¹ to group NH in formula (I), wherein G² means phenyl, G³ is bound to G² in the para position of G² in relation to G¹, and wherein provided G² represents 1,3-thiazolyl or 1,3-oxazolyl, G² is bound to G¹ in the position of 5 G² and G³ is bound to G² in the position of 2 G²; T in each case is independently specified in a group containing C_1-6alkyl and halogen; G³ is presented by formula or by formula ; W¹ is -C(R³)(R⁴)-C(R³)(R⁴)-, and W² represents N; or W³ represents O; W⁴ is -C(R³)(R⁴) -; each R³ and R⁴ is hydrogen; each R⁵ and R⁶ kis hydrogen; R^c and R^d together with a carbon atom whereto attached, are a 4-5-member cycloalkyl or monocyclic heterocycle of formula ; wherein one hydrogen atoms attached to the carbon atom of the cycloalkyl ring and monocyclic heterocycle is optionally substituted by a radical specified in a group -C(O)O(R⁸); W⁵ is -CH₂- or -CH₂-CH₂-; W⁶ is O or N(R^X), wherein R^x is hydrogen, C_1-6alkyl or -C(O)O(R^z); R^Z in each case is independently C_1-6alkyl; R⁸ is hydrogen; L¹ is O; and X is hydrogen, C_1-6alkyl, or - (CR^gR^h)_u-C(O)O(R¹⁰); or L¹ is -CH₂- and X is -C(O)OH; R¹⁰ is hydrogen; or Q is G⁴ or Y¹-Y³; or Q is described for formula wherein Z is phenyl; G⁴ is benzothiazole or benzoxazole optionally additionally substituted by 1 or 2 substitutes specified in a group consisting of C_1-6alkyl, halogen and -OR¹; Y¹ in each case is independently -C(O)-, -C(O)O- or -C(O)N(R^w)-, wherein the right side -C(O)O- and -C(O)N(R^w)- of the groups is attached to Y³ or (CR^JR^k)_v, Y³ in each case is independently phenyl, benzyl, piperidinyl or bicyclo[4.2.0]octa-1,3,5-triene, wherein the phenyl and benzyl residues are optionally additionally substituted by 1 or 2 substitutes specified in a group consisting of halogen and haloC_1-6alkyl; R^g and R^h in each case is independently hydrogen, or C_1-6alkyl; R¹ in each case is independently halogenC_1-6alkyl; R^w is hydrogen; and u means 1.

EFFECT: compounds being the type 1 diacylglycerol O-acyltransferase (DGAT-1) enzyme inhibitors.

7 cl, 1 tbl, 61 ex