INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME Russian patent published in 2013 - IPC C07D231/12 C07D231/20 C07D241/12 C07D249/08 C07D263/34 C07D277/42 C07D403/10 C07D405/12 C07D413/12 C07D413/14 A61K31/4152 A61K31/455 A61K31/4162 A61K31/4196 A61K31/421 A61K31/422 A61K31/426 A61K31/4965 A61P1/16 A61P3/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, where Q is phenyl or pyridinyl; A is pyrazolyl or triazolyl, where each A is independently additionally unsubstituted or substituted with 1 or 2 substitutes represented by R^a, or A is formula (a); V_a is C(R⁴), V_b is N or C(R⁵) and V_c is N; or V_a is N, V_b is C(R⁵) and V_c is N or C(R⁶); R⁴ is hydrogen, R⁵ is hydrogen, C_1-6alkyl, -OR^b, -SR^b, aryl, selected from phenyl, heteroaryl, selected from thienyl, or cycloalkyl, selected from cyclopropyl; R⁶ is hydrogen or aryl, selected from phenyl; R⁷ is hydrogen or C_1-6alkyl; R³ is hydrogen, C_1-3alkyl, -OH, -S(O)₂R¹, or heteroaryl, selected from tetrazolyl, where the heteroaryl is bonded to a nitrogen atom through a ring carbon atom; R^b, R^x, R^y, R^za, R^zb, R^w, R^e, R^k, R^m, Rⁿ, R^q and R¹, in each case, are independently hydrogen, C_1-3alkyl or C_1-3haloalkyl; and R^f, in each case, is independently hydrogen, C_1-3alkyl or -OH (the rest of the substitutes assume values given in the claim). The invention also relates to a pharmaceutical composition, having inhibiting action on DGAT-1, which contains a compound of formula (I), and a treatment method.

EFFECT: compounds of formula (I) as DGAT-1 inhibitors are provided.

16 cl, 9 dwg, 1 tbl, 127 ex