FIELD: biotechnologies.
SUBSTANCE: invention proposes compounds of labyrinthpeptins A1, A2, or A3 of formula (I) 
, where {A}, {B}, {C}, R1-R6, m and n have the values specified in the formula of the invention. Compounds are obtained at fermentation of Actinomadura namibiensis DSM 6313 strain under acceptable conditions in cultural environment till one or more compounds of formula (I) are formed. The invention proposes the deoxyribonucleic acid (DNA) coding preprolabyrinthpeptin A2, and the deoxyribonucleic acid (DNA) coding preprolabyrinthpeptin A1, as well as preprolabyrinthpeptins A1 and A2, and prolabyrinthpeptins A1 and A2. Labyrinthpeptins of formula (I) are used for therapy of infections caused by gram-positive bacteria, virus infections and/or neuropathic pain caused by inflammation.
EFFECT: improving therapy efficiency.
24 cl, 4 tbl, 20 ex
| Title | Year | Author | Number |
|---|---|---|---|
| FIVE-MEMBERED HETEROCYCLES AS INHIBITORS OF LEUKOCYTE ADHESION AND VLA-4 ANTAGONISTS | 1997 |
|
RU2229296C2 |
| PYRAZOLE COMPOUNDS AND THEIR APPLICATION IN METHOD OF FIGHTING INVERTEBRATE PESTS, IN METHOD OF PROTECTION OF PLANT REPRODUCTION MATERIAL, IN METHOD OF TREATMENT OR PROTECTION OF ANIMALS AGAINST INVASION OR INFECTION, IN MATERIAL OF PLANT REPRODUCTION AND AGRICULTURAL COMPOSITIONS CONTAINING THEREOF | 2008 |
|
RU2516290C2 |
| DERIVATIVES OF 1,3-DIARYL-2-PYRIDINE-2-YL-3-(PYRIDINE-2-YLAMINO)PROPANOL AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 1999 |
|
RU2224748C2 |
| SUBSTITUTED BENZAMIDES FOR ARTHROPODA CONTROL | 2014 |
|
RU2712092C2 |
| DERIVATIVES OF PHENYLUREA SUBSTITUTED WITH CARBOXYLIC ACID AMIDE AND THEIR USING AS MEDICINAL AGENTS | 2002 |
|
RU2291858C2 |
| ANTIBACTERIAL PEPTIDES OF ACTINOMADURA NAMIBIENSIS | 2007 |
|
RU2451028C2 |
| ISOQUINOLINE DERIVATIVES AS Rho-KINASE INHIBITORS | 2006 |
|
RU2443688C2 |
| SUBSTITUTED ISOQUINOLINE AND ISOQUINOLINONE DERIVATIVES AS Rho-KINASE INHIBITORS | 2007 |
|
RU2455302C2 |
| COSMETIC PREPARATION FOR PROTECTING SKIN AND HAIR OF MAN AND ANIMALS AGAINST HARMFUL ACTIONS OF ULTRAVIOLET RADIATION, METHOD OF PROTECTION MAN'S HAIR, AND ALSO NEW COMPOSITIONS OF BENZOTRIAZOLE | 1997 |
|
RU2194493C2 |
| NEW CYCLOALKYL DERIVATIVES AS INHIBITORS OF BONE RESORPTION AND ANTAGONISTS OF VITRONECTINE RECEPTOR | 1997 |
|
RU2180331C2 |
