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2 498 995

(13)

(51)

IPC

C07K14/36(2006-01-01)

C07K7/08(2006-01-01)

A61P31/04(2006-01-01)

A61P31/12(2006-01-01)

C12P21/02(2006-01-01)

A61K38/10(2006-01-01)

(21) (22)

Application

2010144778/10, 2009-03-18

(24)

Start date

2009-03-18

(22)

Actual filing date

2009-03-18

(45)

Published

2013-11-20

(72)

Inventor

Brenstrup MarkGjuring KhansKhoffmann Khol'GerVink JoakhimZjussmut RoderikhShmiderer Timo

(73)

Holder

Sanofi-Aventis

PEPTIDES WITH LARGE NUMBER OF BRIDGE LINKS, WHICH ARE EXTRACTED FROM ACTINOMADURA NAMIBIENSIS Russian patent published in 2013 - IPC C07K14/36 C07K7/08 A61P31/04 A61P31/12 C12P21/02 A61K38/10

Abstract RU 2498995 C2

FIELD: biotechnologies.

SUBSTANCE: invention proposes compounds of labyrinthpeptins A1, A2, or A3 of formula (I) , where {A}, {B}, {C}, R₁-R₆, m and n have the values specified in the formula of the invention. Compounds are obtained at fermentation of Actinomadura namibiensis DSM 6313 strain under acceptable conditions in cultural environment till one or more compounds of formula (I) are formed. The invention proposes the deoxyribonucleic acid (DNA) coding preprolabyrinthpeptin A2, and the deoxyribonucleic acid (DNA) coding preprolabyrinthpeptin A1, as well as preprolabyrinthpeptins A1 and A2, and prolabyrinthpeptins A1 and A2. Labyrinthpeptins of formula (I) are used for therapy of infections caused by gram-positive bacteria, virus infections and/or neuropathic pain caused by inflammation.

EFFECT: improving therapy efficiency.

24 cl, 4 tbl, 20 ex

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RU 2 498 995 C2

Authors

Brenstrup Mark

Gjuring Khans

Khoffmann Khol'Ger

Vink Joakhim

Zjussmut Roderikh

Shmiderer Timo

Dates

2013-11-20—Published

2009-03-18—Filed