ALKYL [(S)-1-((S)-2-{5-[4-(4-{2-[(S)-1-((S)-2-METHOXYCARBONYLAMINO-3-METHYL-BUTYRYL)-PYRROLIDIN-2-YL]-3H-IMIDAZOL-4-YL}-BUTA-1,3-DIINYL)-PHENYL]-1H-IMIDAZOL-2-YL}-PYRROLIDINE-1-CARBONYL)-2-METHYL-PROPYL]-CARBAMATE NAPHTHALENE-1,5-DISULPHONATE, PHARMACEUTICAL COMPOSITION, MEDICINAL AGENT, METHOD OF TREATING VIRAL DISEASES Russian patent published in 2014 - IPC C07D403/04 C07C303/32 A61K31/4178 A61P31/12 

Abstract RU 2507201 C1

FIELD: chemistry.

SUBSTANCE: present invention relates to novel alkyl [(S)-1-((S)-2-{5-[4-(4-{2-[(S)-1-((S)-2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-buta-1,3-diinyl)-phenyl]-1H-imidazol-2-yl}pyrrolidine-1-carbonyl)-2-methyl-propyl]-carbamate naphthalene-1,5-disulphonates of general formula 1, which are NS5A inhibitors and can be used as an active component for producing a pharmaceutical composition and an antiviral medicinal agent for treating and preventing viral diseases caused by hepatitis C virus (HCV) and hepatitis GBV-C virus. In general formula 1 R denotes C1-C3alkyl.

EFFECT: obtaining novel compounds.

6 cl, 2 tbl, 6 ex

Similar patents RU2507201C1

Title Year Author Number
ALKYL [2-(2-{5-[4-(4-{2-[1-(2-METHOXYCARBONYLAMINO-ACETYL)-PYRROLIDIN-2-YL]-3H-IMIDAZOL-4-YL}-PHENYL)-BUTA-1,3-DIINYL]-1H-IMIDAZOL-2-YL}-PYRROLIDIN-1-YL)-2-OXO-ETHYL]-CARBAMATE, PHARMACEUTICAL COMPOSITION, MEDICATION, METHOD OF TREATING VIRAL DISEASES 2013
  • Ivashchenko Aleksandr Vasil'Evich
  • Mit'Kin Oleg Dmitrievich
RU2518369C1
NUCLEOSIDE INHIBITORS OF RNA-POLYMERASE HCV NS5B, METHODS FOR PRODUCTION AND USE THEREOF 2014
  • Ivashchenko Aleksandr Vasil'Evich
RU2567854C1
SUBSTITUTED AZOLES, ANTIVIRAL ACTIVE COMPONENT, PHARMACEUTICAL COMPOSITION, SYNTHESIS AND APPLICATION METHOD 2010
  • Ivashchenko Aleksandr Vasil'Evich
  • Bychko Vadim Vasil'Evich
  • Mit'Kin Oleg Dmitrievich
RU2452735C1
ALKYL2-{[(2R,3S,5R)-5-(4-AMINO-2-OXO-2H-PYRIMIDINE-1-YL)- -HYDROXY- TETRAHYDRO-FURAN-2-YLMETHOXY]-PHENOXY-PHOSPHORYLAMINO}-PROPTONATES, NUCLEOSIDE INHIBITORS OF RNA-POLYMERASE HCV NS5B, METHODS FOR PRODUCING AND USING THEM 2013
  • Ivashchenko Aleksandr Vasil'Evich
RU2534613C2
CYCLOBUTYL (S)-2-[[[R)-2-(6-AMINOPURIN-9-YL)-1-METHYL-ETOXY]METHYL-PHENOXY-PHOSPHORYL]AMINO]-PROPANOATES, METHOD OF THEIR PRODUCTION AND APPLICATION 2017
  • Aleksandr Vasilevich Ivashchenko
  • Mitkin Oleg Dmitrievich
RU2647576C1
SUBSTITUTED (2R,3R,5R)-3-HYDROXY-(5-PYRIMIDIN-1-YL)TETRAHYDROFURAN-2-YLMETHYL ARYL PHOSPHORAMIDATES 2013
  • Ivashchenko Andrej Aleksandrovich
  • Ivashchenko Aleksandr Vasil'Evich
  • Mit'Kin Oleg Dmitrievich
RU2553996C1
ANTIVIRAL COMPOSITION AND METHOD OF ITS APPLICATION 2017
  • Aleksandr Vasilevich Ivashchenko
  • Mitkin Oleg Dmitrievich
RU2650610C1
NUCLEOTIDES INCLUDING N-[(S)-1-CYCLOBUTOXYCARBONYL]PHOSPHORAMIDATE FRAGMENT, THEIR ANALOGS AND THEIR APPLICATION 2017
  • Aleksandr Vasilevich Ivashchenko
  • Mitkin Oleg Dmitrievich
RU2659388C1
PANGENOTYPIC NS5A PROTEIN INHIBITOR OF HEPATITIS C VIRUS, A PHARMACEUTICAL COMPOSITION AND METHODS FOR PREPARING AND USING 2019
  • Ivashchenko Andrej Aleksandrovich
  • Ivashchenko Aleksandr Vasilevich
  • Mitkin Oleg Dmitrievich
RU2723482C1
PRODRUG OF POLYMERASE NS5B HCV INHIBITOR, METHOD FOR ITS PREPARATION AND APPLICATION 2017
  • Ivashchenko Aleksandr Vasilevich
  • Mitkin Oleg Dmitrievich
RU2644156C1

RU 2 507 201 C1

Authors

Ivashchenko Aleksandr Vasil'Evich

Dates

2014-02-20Published

2013-02-07Filed