ANTIVIRAL COMPOSITION AND METHOD OF ITS APPLICATION Russian patent published in 2018 - IPC A61K31/7072 A61K9/08 A61K9/20 A61K9/48 A61P31/12 

FIELD: pharmaceutics.

SUBSTANCE: group of inventions refers to chemical and pharmaceutical industry and is an antiviral pharmaceutical composition for treating a hepatitis C virus in a subject in need thereof, which contains an effective amount of a prodrug selected from cyclobutyl (S)-2-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-ylmethoxy]-phenoxy-phosphorylamino}-propanoate of general formula 1, and/or cyclobutyl (S)-2-{(S)-[(2R,3R,4R,5R)-5-(3,4-dihydro-2,4-dioxo-2H-pyrimidin-1-yl)-3-hydroxy-4-methyl-4-fluoro-tetrahydro-furan-2-ylmethoxy]-phenoxy-phosphorylamino}-propanoate of the formula 1.1, and/or cyclobutyl (S)-2-{(R)-[(2R,3R,4R,5R)-5-(3,4-dihydro-2,4-dioxo-2H-pyrimidin-1-yl)-3-hydroxy-4-methyl-4-fluoro-tetrahydro-furan-2-ylmethoxy]-phenoxy-phosphorylamino}-propanoate of the formula 1.2, their crystalline or polycrystalline form and a pharmaceutically acceptable carrier.

Group of inventions also includes a method of treating hepatitis C in a subject in need thereof, including a sequential or simultaneous administration of a therapeutically effective amount of the antiviral pharmaceutical composition described above.

EFFECT: this new antiviral composition is more effective than known pharmaceutical antiviral compositions.

11 cl, 4 tbl, 9 ex