METHOD OF EXTRACTING NOVOCAINE FROM AQUEOUS MEDIA WITH MIXTURE OF PHENETOLE AND ETHYL ACETATE Russian patent published in 2014 - IPC G01N33/15 B01D11/04 

FIELD: chemistry.

SUBSTANCE: method of extracting novocaine from aqueous media with a mixture of phenetole and ethyl acetate, characterised by that it involves preparing an aqueous salt solution of novocaine by placing aqueous novocaine solution with known concentration into a measuring flask, making up to volume with a saturated solution of a salting-out agent in form of ammonium sulphate, extracting novocaine with a mixture of phenetole and ethyl acetate, taken in ratio of 1:1, by adding to the obtained aqueous salt solution of novocaine an extraction agent in form of a mixture of phenetole and ethyl acetate (1:1) with the ratio of the volume of the phases of the aqueous salt solution of novocaine to the extraction agent of 5:1, extracting on a vibratory blender until inter-phase equilibrium is established, after demixing of the system, separating the aqueous salt solution from the organic phase and analysing by UV spectrophotometry, measuring optical density of the aqueous salt solution on a UV spectrophotometer at wavelength of 291 nm and on a calibration curve which is plotted in coordinates of optical density of the aqueous salt solution and concentration of novocaine, finding content of novocaine in the aqueous medium; using the concentration to calculate the distribution coefficient and degree of extraction of novocaine.

EFFECT: method enables to completely extract novocaine from aqueous media, intensifies the extraction process, provides rapid and accurate determination of concentration of novocaine.

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