METHOD FOR PREPARING STERILE SELF-GELLING ALGINATE SYSTEM Russian patent published in 2014 - IPC A61K9/10 A61K31/734 A61K31/10 A61K47/12 

FIELD: medicine.

SUBSTANCE: method for preparing involves forming a dispersion of water-soluble sodium alginate and particles with gelling calcium ions; water-soluble sodium alginate is introduced into calcium carbonate directly in the concentration of 0.08-0.12 wt %, and adding organic acid specified in 2,4-hexanediene, para-toluic, 4-propyloxybenzoic in an amount of 0.12-0.36 wt % with the ratio of calcium salt and the above acids of 2:3, 1:2, 1:3 respectively. The prepared alginate system is settled to form a gel matrix at room temperature that is followed by γ-sterilisation.

EFFECT: hydrogel matrixes hold the shape stability after the γ-sterilisation procedure, possess the excellent tactile properties being soft and elastic, provide the targeted prolonged drug delivery.

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