FIELD: medicine.
SUBSTANCE: invention refers to medicine, particularly to a method for active substance (AS) delivery through an epidermal barrier. The declared method involves using a matrix-type transdermal patch containing a substrate, a protective tape and a polymer layer, and characterised by the fact that 10% PEG-12 dimethicone niosomes are introduced into the polymer layer of the transdermal patch; then the substrate is coated with the polymer layer. The ACs are encapsulated into the niosomes with the use of hemogeniser APV, as well as 10 wt % propylene glycol and 5 wt % isopropyl myristate.
EFFECT: improving the active substance penetration with maintaining the biological activity and prolonging the active substance action.
2 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR TRANSDERMAL TRANSFER OF ACTIVE SUBSTANCES WITH USE OF PEG-12 DIMETHICONE NIOSOMES | 2012 |
|
RU2539396C2 |
| DOXORUBICIN AND ORGANOSILICON NANOPARTICLES-NIOSOMES- BASED PHARMACEUTICAL GEL FOR SKIN CANCER TREATING | 2014 |
|
RU2600164C2 |
| DENTAL GEL HAVING NIOSOMES FOR TREATMENT OF INFLAMMATORY AND DYSTROPHIC PERIODONTAL DISEASES | 2013 |
|
RU2582290C2 |
| PHARMACEUTICAL NIOSOMAL GEL BASED ON N-HYDROXY-2-(2-(NAPHTALENE-2-YL)-1H-INDOLE-3-YL)-2-PHENYLACETAMIDE WITH ANTI-TUMOUR ACTIVITY TO GLIOBLASTOMA | 2015 |
|
RU2627449C2 |
| TRANSDERMAL ANTHELMINTIC AGENT OF SILICONE NIOSOMES WITH ALBENDAZOLE | 2013 |
|
RU2541156C1 |
| REGENERIN SERUM FOR EXTERNAL APPLICATION WITH ANTI-INFLAMMATORY AND REGENERATIVE EFFECT | 2011 |
|
RU2469704C1 |
| TRANSDERMAL GEL FOR AREA AROUND EYES "SILKY TOUCH" | 2007 |
|
RU2383328C2 |
| SYSTEM FOR DELIVERY OF BIOACTIVE SUBSTANCES BY USING NIOSOMES | 2006 |
|
RU2320323C1 |
| TRANSDERMAL GEL FOR FACE 'STVOLIN" | 2007 |
|
RU2376974C2 |
| MOISTENING SERUM FOR FACE "VITA" | 2007 |
|
RU2376982C2 |
