N-PYRIDIN-3-YL OR N-PYRAZIN-2-YL CARBOXAMIDES AS AGENTS INCREASING LEVEL OF HDLP CHOLESTEROL Russian patent published in 2015 - IPC C07D213/75 C07D401/12 C07D403/12 C07D407/12 C07D413/12 C07D417/12 C07D498/04 A61K31/444 A61K31/4965 A61P9/00 

FIELD: chemistry.

SUBSTANCE: invention relates to field of organic chemistry, namely to heterocyclic compounds of formula I

and to their pharmaceutically acceptable salts, where A is selected from CH or N; R¹ is selected from the group, consisting of C3-6-cycloalkyl, C3-6-cycloalkyl-C1-7-alkyl, C1-7-alkoxy-C1-7-alkyl, halogen-C1-7-alkyl; R² and R⁶ independently on each other represent hydrogen of halogen; R³ and R⁵ independently on each other are selected from the group, consisting of hydrogen, C1-7-alkyl and halogen; R⁴ is selected from the group, consisting of hydrogen, C1-7-alkyl, halogen and amino; R⁷ is selected from the group, consisting of C1-7-alkyl, C1-7alkoxy-C1-7-alkyl, C1-7-alkoxyimino-C1-7-alkyl, 4-6-membered heterocyclyl, containing one heteroatom O, phenyl, with said phenyl being non-substituted or substituted with one hydroxy group, and 5-10-membered heteroaryl, containing 1-3 heteroatoms, selected from N, S and O, said heteroaryl is not substituted or is substituted with one or two groups, selected from the group, consisting of C1-7-alkyl, hydroxy, C1-7-alkoxy, cyano, C1-7-alkylaminocarbonyl and halogen. Invention also relates to pharmaceutical composition based on formula I compound and to method of obtaining formula I compound.

EFFECT: obtained are novel heterocyclic compounds, which are agents, increasing level of LDLP.

17 cl, 2 tbl, 89 ex