3-PYRIDINE CARBOXAMIDE AND 2-PYRAZINE CARBOXAMIDE DERIVATIVES AS HDL-CHOLESTEROL RAISING AGENTS Russian patent published in 2012 - IPC C07D213/63 C07D213/74 C07D241/24 A61K31/465 A61K31/4965 A61P9/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula I:

, where A denotes CH or N; R¹ is selected from a group consisting of: cycloalkyl which is unsubstituted or substituted with hydroxy, lower hydroxyalkyl or lower alkoxy, 1-hydroxy-2-indanyl, lower hydroxyalkyl, lower hydroxy haloalkyl, lower hydroxy alkoxyalkyl, CH₂-CR⁹R¹⁰-cycloalkyl and -CR¹¹R¹²- COOR¹³; R⁹ denotes hydrogen or lower alkyl; R¹⁰ denotes hydrogen, hydroxy or lower alkoxy; R¹¹ and R¹² independently denote hydrogen or lower alkyl; R¹³ denotes lower alkyl; R² denotes hydrogen; or R¹ and R² together with the nitrogen atom with which they are bonded form a morpholinyl ring; R¹⁵ is selected from a group consisting of lower alkoxyalkyl, cycloalkyl and furanyl, substituted with halogen; R¹⁷ is selected from a group consisting of hydrogen, lower alkyl and lower haloalkyl; R⁴ and R⁸ independently denote hydrogen or halogen; R⁵ and R⁷ are independently selected from a group consisting of hydrogen, lower alkyl, lower alkoxy, halogen, lower haloalkyl, lower haloalkoxy and cyano; R⁶ is selected from a group consisting of hydrogen, lower alkoxy, halogen, lower haloalkyl, lower haloalkoxy and cyano; and pharmaceutically acceptable salts thereof. The invention also relates to use of said compounds to produce medicinal agents for treating and/or preventing diseases which can be cured by HDL-cholesterol raising agents and to a pharmaceutical composition based on said compounds.

EFFECT: novel compounds which can be useful in treating diseases which can be treated with HDL-cholesterol raising agents are obtained and described.

36 cl, 164 ex