FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to new carboxamide compounds of formula such as below, their tautomers and pharmaceutically acceptable salts, wherein the values R1, R2, R3a, R3b, R4, Q, Y, A and X are presented in clause 1 of formula .
EFFECT: compounds are cell calpain (calcium-dependent cysteine protease) inhibitors that makes them applicable for treating some diseases related to high activity of calpain.
33 cl, 2 tbl, 75 ex, 7 dwg
Title | Year | Author | Number |
---|---|---|---|
CARBOXAMIDE COMPOUNDS AND USE THEREOF AS CALPAIN INHIBITORS | 2010 |
|
RU2567392C2 |
CALPAIN MODULATORS AND THEIR THERAPEUTIC USE | 2017 |
|
RU2773288C2 |
AMINOTETRALINE DERIVATIVES CONTAINING THEIR PHARMACEUTICAL COMPOSITIONS AND USING THEM IN THERAPY | 2010 |
|
RU2546649C2 |
SUBSTITUTED CHROMANS | 2015 |
|
RU2718060C2 |
ANTIVIRAL COMPOUNDS | 2010 |
|
RU2541571C2 |
DIAZAHOMOADAMANTANE DERIVATIVES AND METHODS OF USING THEM | 2010 |
|
RU2549551C2 |
COMPOUNDS AND METHODS FOR USING | 2009 |
|
RU2561109C2 |
INHIBITOR CONTAINING A TRICYCLIC DERIVATIVE, A METHOD OF ITS PRODUCTION AND ITS USE | 2019 |
|
RU2800543C2 |
THERAPEUTIC ANTIDIABETIC AGENT | 2006 |
|
RU2438671C2 |
SUBSTITUTED (2R,3R,5R)-3-HYDROXY-(5-PYRIMIDIN-1-YL)TETRAHYDROFURAN-2-YLMETHYL ARYL PHOSPHORAMIDATES | 2013 |
|
RU2553996C1 |
Authors
Dates
2015-02-10—Published
2010-05-06—Filed