MASP-2 INHIBITORS AND METHODS OF USE THEREOF Russian patent published in 2024 - IPC C07D207/00 C07D205/04 C07D213/00 C07D211/80 C07D401/12 C07D417/12 C07D403/04 A61K31/472 A61K31/445 A61K31/517 A61K31/397 A61P13/12 A61P29/00 

Abstract RU 2832708 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I-1) or a pharmaceutically acceptable salt thereof, where Cy1A is substituted phenyl or unsubstituted or substituted 5–10 membered heteroaryl; wherein the ring atoms of 5–10-membered heteroaryl forming Cy1A consist of carbon atoms and 1, 2 or 3 heteroatoms selected from O, N and S, n1 is equal to 1 or 2 and n2 is equal to 1, which has MASP-2 inhibitory activity, a pharmaceutical composition based thereon and use for preparing a drug for inhibiting MASP-2.

EFFECT: novel compounds which can be used to produce a drug for treating MASP-2-related diseases or disorders are obtained.

21 cl, 38 tbl, 315 ex, 76 dwg

Similar patents RU2832708C2

Title Year Author Number
NEW CONJUGATES BINDING COMPOUND - ACTIVE COMPOUND (ADC) AND USE THEREOF 2012
  • Lerkhen Khans-Georg
  • Linden Lars
  • El Shejkh Sherif
  • Villuda Jorg
  • Kopitts Sharlotte Kristine
  • Shumakher Ioakhim
  • Greven Zimone
  • Malert Kristof
  • Shtelte-Lyudvig Beatriks
  • Golfir Sven
  • Bajer Rudolf
  • Khajsler Iring
  • Kharrenga Aksel
  • Tiraukh Karl-Khajnts
  • Bruder Zandra
  • Petrul Khajke
  • Iorissen Khanna
  • Borkovski Zandra
RU2610336C2
CALICHEAMICIN DERIVATIVES AND THEIR ANTIBODY-DRUG CONJUGATES 2018
  • Ahmad, Omar Khaled
  • Brown, Stephen Paul
  • Dirico, Kenneth John
  • Dushin, Russell
  • Filzen, Gary Frederick
  • Puthenveetil, Sujiet
  • Strop, Pavel
  • Subramanyam, Chakrapani
  • Tumey, Lawrence N.
RU2732568C1
DERIVATIVES OF DOLAPROIN-DOLAIZOLEIN PEPTIDES 2015
  • Mendelson Brajan Alan
  • Dyugal-Tecce Zhyulen
  • Barnsher Styuart Deniel
RU2747989C2
COMPOUNDS SUITABLE FOR THERAPY AGAINST HIV 2019
  • De La Rosa Marta Alisia
  • Dankhem Richard M
  • Margolis Devid
  • Tai Vinsent Uing-Fai
  • Tang Dzhun
RU2806030C2
CYTOTOXIC PEPTIDES AND ANTIBODY-DRUG CONJUGATES THEREOF 2012
  • Doroski Matthew David
  • Maderna Andreas
  • O'Donnell Christopher John
  • Subramanyam Chakrapani
  • Vetelino Beth Cooper
  • Dushin Russell George
  • Strop Pavel
  • Graziani Edmund Idris
RU2586885C2
SERINE DERIVATIVES AS GHRELIN RECEPTOR AGONISTS 2015
  • Iwata, Yasuhiro
  • Kawamura, Kiyoshi
  • Sudo, Masaki
  • Shimada, Kaoru
  • Koizumi, Shinichi
  • Takahashi, Nobuyuki
  • Obata, Keiko
  • Kuroda, Makiko
RU2695649C2
ANTHELMINTHIC DEPSIPEPTIDE COMPOUNDS 2016
  • Le Hir De Fallois, Loic
  • Pacofsky, Gregory
  • Long, Alan
  • Meng, Charles
  • Lee, Hyoung, Ik
RU2715556C2
3-(5-HYDROXY-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASES ASSOCIATED WITH ZINC FINGER PROTEIN 2 (IKZF2) OF THE IKAROS FAMILY 2019
  • Adcock, Claire
  • Bonazzi, Simone
  • Cernijenko, Artiom
  • Lam, Philip
  • Linkens, Kathryn Taylor
  • Malik, Hasnain Ahmed
  • Thomsen, Noel Marie-France
  • Visser, Michael Scott
RU2797559C2
ANTHELMINTHIC DEPSIPEPTIDE COMPOUNDS 2016
  • De Fallois, Loic, Le Hir
  • Pacofsky, Gregory
  • Long, Alan
  • Meng, Charles
  • Lee, Hyoung, Ik
  • Ogbu, Cyprian, O.
RU2707298C2
INHIBITOR CONTAINING A TRICYCLIC DERIVATIVE, A METHOD OF ITS PRODUCTION AND ITS USE 2019
  • Gao Peng
  • Sun Guangjun
  • Wang Shaobao
  • Xiu Wenhua
  • Tan Songliang
  • Bao Rudi
RU2800543C2

RU 2 832 708 C2

Authors

Katshell, Nil S.

Gejdzh, Dzhennifer Linn

Grusvitts, Frants A.

Kkhalaf, Dzhukhienakh

Littl, Tomas L.

Ngujen, Dzheremaya Kh.

Nollert Fon Shpekht, Piter Kurt

Tsoung, Dzhennifer

Chichirelli, Majkl

Metts, Markus

Goldshtejn, Sara Rebekka

Keshipeddi, Santosh Kumar

Kvon, Do Jon

Lemus, Robert Uerta

Vaddela, Sudkhir Babu

Dates

2024-12-27Published

2019-05-28Filed