METHOD FOR PRODUCING DRUG MICROCAPSULES OF CEPHALOSPORINS IN KONJAK GUM IN HEPTANE Russian patent published in 2015 - IPC A61K31/545 A61K9/50 A61K47/36 A61J3/07 B01J13/02 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to a method for producing drug microcapsules of cephalosporins in konjak gum in heptanes. The declared method is characterised by the fact that 5% konjak gum in heptane 6 g is added with the preparation E472c 0.01 g as a surfactant; the prepared mixture is placed on a magnetic mixer, and an agitation mode is actuated. Then, the mixture is added into a solution of konjak gum in heptanes of the cephalosporin powder 0.1 g dissolved in ethanol 0.5 ml; after cephalosporin forms an independent solid phase, carbinol 5ml and distilled water 1 ml is added very slowly drop-by-drop. The prepared suspension of microcapsules is filtered, washed in acetone, dried in a desiccator over calcium chloride; the method is performed at 25°C.

EFFECT: reducing microcapsule production loss and increasing weight yield.

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