METHOD FOR PREDICTION OF EFFICACY OF ANTIVIRAL TREATMENT OF CHRONIC VIRAL HEPATITIS C Russian patent published in 2015 - IPC G01N33/49 

FIELD: medicine.

SUBSTANCE: predicting the efficacy of a combined antiviral therapy (AVT) of chronic hepatitis C (CHC) with using regression analysis is ensured by calculating a virology response prediction coefficient (VRPC). VRPC=-3.581+eosinoph. *0.073- monocytes *0.012+lymphocytes *0.0772- bilirubin *0.098+ALT*0.7357+glucose *0.1049, wherein eosinoph. is the respective (%) eosinophil count in peripheral blood; monocytes is the respective (%) monocyte count in peripheral blood; lymphocytes is the respective (%) lymphocyte count in peripheral blood; bilirubin is total indirect bilirubin in venous blood, mcmole/l; ALT is the alanine-aminotransferase amount in venous blood, units per litre; glucose is the glucose amount, mmole/l. If the derived VRPC value is 319 or less, the absence of the stable virology response is predicted. If the VRPC value is more than 319, the stable virology response formed by the antiviral treatment is predicted.

EFFECT: using the given method enables predicting the antiviral therapeutic outcome by a personalised approach, and individualising the selection of a therapeutic sequence.

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