FIELD: chemistry.
SUBSTANCE: invention relates to a chitosan derivative, wherein a chitosan fragment of general formula (I) , where R is a fatty or amino acid residue, n for a hydrophilic ligand ranges from about 12% to about 25% with respect to the number of monosaccharide residues of chitosan, m for a hydrophobic ligand ranges from about 30% to about 60% with respect to the number of monosaccharide residues of chitosan. The invention also relates to versions of a method of producing said derivative.
EFFECT: invention provides a chitosan derivative with high transdermal and membrane permeability, high sorption capacity and solubility in a wide pH range.
16 cl, 2 dwg, 2 ex, 1 tbl
Title | Year | Author | Number |
---|---|---|---|
APPLICATION OF CHITOSAN DERIVATIVE FOR SELECTIVE DELIVERY OF MEDICATIONS AND BIOLOGICALLY ACTIVE COMPLEXES | 2013 |
|
RU2561062C2 |
CHITOSAN PRODUCT, METHOD FOR ITS PREPARING (VARIANTS) | 2005 |
|
RU2313538C2 |
POLYMERS WITH CARBOHYDRATE SIDE GROUPS AND USE THEREOF | 2011 |
|
RU2541534C2 |
METHOD FOR FORMING CHITOSAN FILM COATING AND CHITOSAN FILM COATING | 2010 |
|
RU2461575C2 |
MONOMETHYL AURISTATIN E CONJUGATE FOR PREPARING A COMPOSITION FOR TREATING PROSTATE CANCER | 2019 |
|
RU2729192C1 |
STENT | 2007 |
|
RU2432183C9 |
CONJUGATE OF A FLUORESCENT DYE WITH A PEPTIDE SUBSTANCE WHICH CONTAINS A PSMA-BINDING LIGAND BASED ON A UREA DERIVATIVE FOR VISUALIZING CELLS EXPRESSING PSMA, A METHOD FOR PRODUCTION THEREOF AND USE THEREOF | 2019 |
|
RU2713151C1 |
AGENT FOR TREATING DAMAGE TO EXTERNAL BODY TISSUES (VERSIONS) AND METHOD OF PRODUCING SAME | 2014 |
|
RU2578969C1 |
COMPLEX CARBOXYLATE POLYSACCHARIDE ESTER | 2015 |
|
RU2654031C2 |
PEPTIDE AGENT COMPRISING A PSMA-BINDING LIGAND BASED ON A UREA DERIVATIVE, A METHOD FOR PRODUCTION THEREOF AND USE THEREOF FOR PREPARING A CONJUGATE WITH A DRUG AND DIAGNOSTIC AGENT | 2018 |
|
RU2697519C1 |
Authors
Dates
2015-04-10—Published
2013-12-17—Filed