METHOD FOR FENBENDAZOLE ENCAPSULATION Russian patent published in 2015 - IPC A61K9/50 A61K31/4184 B01J13/06 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to the chemical-pharmaceutical industry and represents a method for drug preparation encapsulation by non-solvent addition differing by the fact that fenbendazole is used as a microcapsule nucleus, whereas a microcapsule coating is sodium carboxymethyl cellulose; herewith fenbendazole 100 mg is dissolved in dimethylsulphoxide, or dioxane, dimethylformamide 1 ml; the prepared mixture is dispersed in a sodium carboxymethyl cellulose solution in isopropanole containing the above polymer 300 mg in the presence of E472c surfactant 0.01 g, and stirred at 1000 rps, added with butanol 2 ml and distilled water 1 ml; the prepared suspension of microcapsules is filtered and dried at 25°C.

EFFECT: invention provides facilitating and accelerating the microencapsulation process, as well as lowered accompanying loss (higher weight yield).

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