METHOD OF FENBENDAZOLE ENCAPSULATION Russian patent published in 2015 - IPC A61K31/4184 A61K47/38 A61K9/58 A61J3/07 B01J13/02 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the field of encapsulation, in particular to a method of obtaining fenbendazole microcapsules in an envelope of sodium carboxymethylcellulose. In accordance with the method fenbendazole is dissolved in dioxane or dimethylsulphoxide, or dimethylformamide, the obtained fenbendazole solution is added to a solution of sodium carboxymethylcellulose in methanol in the presence of E472c with mixing at a rate of 1000 rev/s. Fenbendazole and sodium carboxymethylcellulose are taken in a weight ratio of 1:3. After that ethanol and distilled water, taken in a ratio of 2:1 vol/vol, are added. The obtained suspension of microcapsules is filtered and dried. The process is realised at 25°C for 20 minutes.

EFFECT: invention ensures the simplification and acceleration of the process of obtaining microcapsules, reduction of loss in their obtaining (increase of output by weight).

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