FIELD: medicine.
SUBSTANCE: invention relates to field of immunology. Claimed is isolated antibody to ICOS protein of people with increased effector function. Also described are cell and method of obtaining antibody in accordance with claimed invention, pharmaceutical composition, method of treating autoimmune disease or disorder, transplant rejection and malignancy of human T-cells, as well as method of depletion of ICOS-expressing T-cells, method of destroying germ centre structure in secondary lymphoid organ of primates, methods of depleting B-cells of germ centre of secondary lymphoid organ and circulating B-cells, which have undergone class switching, in primates.
EFFECT: invention can be further applied in therapy of diseases, mediated by T-cells.
33 cl, 21 dwg, 3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| HUMANISED CD19 ANTIBODIES AND USING THEM FOR TREATING TRANSPLANTATION-RELATED ONCOLOGICAL AND AUTOIMMUNE DISEASE | 2007 |
|
RU2495882C2 |
| ANTI-ICOS ANTIBODIES | 2017 |
|
RU2764548C2 |
| ANTIBODIES TO ICOS | 2016 |
|
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| FGFR2 INHIBITORS SEPARATELY OR IN COMBINATION WITH IMMUNOSTIMULATING AGENTS IN CANCER TREATMENT | 2016 |
|
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| FUSION CONSTRUCTS AND THEIR APPLICATION TO CREATE ANTIBODIES WITH HIGH FC RECEPTOR BINDING AFFINITY AND WITH EFFECTOR FUNCTION | 2010 |
|
RU2623167C2 |
| BISPECIFIC ASYMMETRIC HETERODIMERS COMPRISING ANTI-CD3 CONSTRUCTS | 2013 |
|
RU2650868C2 |
| METHOD FOR REDUCING EOSINOPHIL COUNT | 2008 |
|
RU2519227C2 |
| METHOD OF REDUCING BASOPHILS NUMBER | 2014 |
|
RU2618455C2 |
| MICA BINDING AGENTS | 2013 |
|
RU2656183C2 |
| ANTIBODIES TO PD-L1 AND THEIR APPLICATION FOR T-CELLS FUNCTION STRENGTHENING | 2009 |
|
RU2636023C2 |
