NOVEL TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING IT Russian patent published in 2015 - IPC C07D251/46 C07D401/06 C07D401/12 C07D403/04 C07D403/06 C07D403/12 C07D405/06 C07D405/12 A61K31/5377 A61P13/08 A61P25/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to compounds of formula (I) and their pharmaceutically acceptable salts, possessing antagonistic activity with respect to P2X₃- and/or P2X_2/3-receptor. In formula R^a, R^b and R^c represent (a) R^a and R^b, taken together, represent =Z; =Z represents =O; R^c stands for group, represented by R^1c; R^1c represents hydrogen, substituted or non-substituted C_1-8alkyl, C_2-8alkenyl, C_3-7cycloalkyl; or (b) R^b and R^c together form bond; R^a stands for group, represented by group -Y-R^1a; R^1a represents substituted or non-substituted C_1-12alkyl, benzyl; -Y- represents -O-, -S-, -N(R⁷)- or -CH₂-; R⁷ represents hydrogen, substituted or non-substituted C_1-8alkyl or R⁷ and R^1a together form substituted with oxogroup 5-membered nitrogen-containing non-aromatic heterocyclic group; n represents integer number, equal 1 or 2; R² represents substituted or non-substituted C_3-7cycloalkyl, substituted or non-substituted phenyl or substituted or non-substituted 5-6-membered heteroaryl, containing one heteroatom, selected from N and S; R³ represents group, represented by formula: where A ring represents C_3-7cycloalkyl; 6-membered non-aromatic heterocyclic group, containing 1-2 heteroatoms, independently selected from N and O; phenyl; 5-6-membered heteroaryl, containing 1-2 heteroatoms, independently selected from N and O, substituted with oxogroup 9-membered heteroaryl, containing 1-2 heteroatoms, independently selected from N and O; s represents integer number from 0 to 2; values of the remaining radicals are presented in invention formula. Invention also relates to pharmaceutical composition, to application of compounds in obtaining medication for treatment and/or prevention of disease, associated with P2X₃- and/or P2X_2/3-receptor, and to method of treating and/or prevention of disease, associated with P2X₃- and/or P2X_2/3-receptor.

EFFECT: obtained are compounds, which can be used in treatment and/or prevention of diseases, associated with P2X₃- and/or P2X_2/3-receptor.

18 cl, 123 tbl, 29 ex