PSMA×CD3 BISPECIFIC SINGLE-CHAIN ANTIBODY HAVING INTERSPECIES SPECIFICITY Russian patent published in 2015 - IPC C07K16/28 C07K16/46 C12N5/10 C12N15/13 C12N15/63 A61K39/395 A61P35/00 A61P37/00 

FIELD: medicine.

SUBSTANCE: present invention refers to biotechnology and immunology, namely to modulating the T-cell immunity in relation to the cells expressing prostate-specific membrane antigen (PSMA). There are disclosed: nucleic acid sequence coding a molecule of the bispecific single-chain antibody according to the invention, an expression vector, a host cell, a method for producing the molecule of the bispecific single-chain antibody, a pharmaceutical composition, using the molecule of the bispecific single-chain antibody according to the invention for producing the pharmaceutical composition for preventing, treating or relieving symptoms of PSMA expression related cancer, and a method for preventing, treating or relieving symptoms of PSMA expression related cancer in an individual. The present invention can find further application in treating PSMA-related diseases.

EFFECT: what is presented is the molecule of the bispecific single-chain antibody contains a first binding domain binding to human and primate Callithrix jacchus (tamarin), Saguinus Oedipus (cotton-top tamarin) and Saimiri sciureus (squirrel monkey) CD3ε(epsilon)-chain epitope containing the sequence Gln-Asp-Gly-Asn-Glu (QDGNE), and a second binding domain binding to PSMA.

20 cl, 57 dwg, 9 tbl, 26 ex