NANODIAMOND- GLYCINE CONJUGATE AND METHOD OF OBTAINING THEREOF Russian patent published in 2015 - IPC A61K31/195 A61K33/44 B82B1/00 B82Y5/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to the pharmaceutical industry, namely to a nanodiamond-glycine conjugate for delivering glycine into an organism. The nanodiamond-glycine conjugate for delivering glycine into the organism represents glycine-modified nanodiamond particles with the particle size of 2-10 nm, containing to 21±3 wt % of glycine, which is a part of the composition of their up to 1 nm thick surface envelope. The method of obtaining the nanodiamond-glycine conjugate for delivering glycine into the organism consists in annealing nanodiamond particles in a gaseous hydrogen flow with the further liquid-phase chlorination of the obtained particles with molecular chlorine, dissolved in carbon tetrachloride under a photochemical impact of visible light and heating, after which the suspension is centrifuged, washed and dried, the chlorine-modified particles are dissolved in a polar solvent with the formation of a suspension, tertiary amine and glycine are added, the obtained mixture is processed with ultrasound for 5-60 min, the mixture is exposed with heating for 12 to 48 h, centrifuged, washed and dried under specified conditions.

EFFECT: conjugate, obtained by the said method, is characterised by the fact that it does not contain fluorine atoms, with higher dispersity and higher glycine content.

4 cl, 11 dwg, 2 tbl