FIELD: medicine, pharmaceutics.
SUBSTANCE: group of inventions relates to medicine and deals with method for stabilisation of protein of human blood plasma with molecular weight higher than 10 kDa by addition of melicitose into solution, which contains protein of human blood plasma with molecular weight higher than 10 kDa, which represents pharmaceutically or biologically important protein of human blood plasma or recombinantly obtained protein of human blood plasma, selected from the group, consisting of FIX, FVIII or HES-G-CSF. Group of inventions also deals with application of melicitose for stabilisation of protein of human blood plasma with molecular weight higher than 10 kDa, where protein represents factor VII, factor IX or HES-G-CSF.
EFFECT: group of inventions provides stabilisation of solution, containing factor VII, factor IX or HES-G-CSF.
26 cl, 6 ex, 11 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| NOVEL STABILIZER FOR PHARMACEUTICAL PROTEINS | 2011 |
|
RU2707090C2 |
| STABLE, ALBUMIN-FREE, LYOPHILIZED COMPOSITION OF RECOMBINANT FACTOR VIII | 1997 |
|
RU2201252C2 |
| METHOD OF PRODUCING FACTOR VIII, HAVING IMPROVED RATIO FVIII:C/FVIII:AG | 2015 |
|
RU2695428C2 |
| STABILISED IX FACTOR AND TREGALOSE- CONTAINING COMPOSITIONS | 2008 |
|
RU2481823C2 |
| NEW PROTECTIVE COMPOSITIONS FOR RECOMBINANT FACTOR VIII | 2009 |
|
RU2510279C2 |
| NEW ALBUMIN-FREE COMPOSITIONS OF FACTOR VIII | 2000 |
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RU2244556C2 |
| METHOD OF PRODUCING LYOPHILIZED PELLETS CONTAINING A VIII FACTOR | 2016 |
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RU2735082C2 |
| PURIFICATION OF FACTOR VIII SUBTYPES | 2018 |
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RU2800431C2 |
| METHOD OF PRODUCING POWDER CONTAINING PROTEIN WHICH IS HUMAN BLOOD COAGULATION FACTOR AND LACTIC ACID-BASED POLYMER | 2016 |
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RU2702740C2 |
| METHOD FOR PRODUCING IMMORTALISED HUMAN CELL, STABLE TRANSFECTED IMMORTALISED HUMAN CELL, METHOD FOR RECOMBINANT PRODUCTION OF TARGET HUMAN PROTEIN, APPLICATION OF TRANSFECTION VECTOR | 2006 |
|
RU2453597C2 |
