FIELD: medicine.
SUBSTANCE: angiogenesis factors in the form of plasmid vectors are introduced directly into gene tissues. Vascular growth factor genes are vectors containing HIF1a, HIF1b, VEGF165, VEGF225 genes in optimum stoichiometric ratio at 50-200 mcg of DNA per cm2 of the ischemic area at an area pitch of 2-10 mm. To provide more effective transfection, a vector solution is added with adjuvants.
EFFECT: formation of adequate vessels and anastomoses with intact vasculature by the combined introduction of four angiogenesis factor genes that least to recovered perfusion and reduced ischemic events.
2 cl, 4 ex, 2 tbl, 4 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF TREATING CORONARY INSUFFICIENCY IN SIMULATED MYOCARDIAL ISCHEMIA | 2010 |
|
RU2444378C1 |
| AGENT FOR TREATMENT OF ISCHEMIC LESIONS OF TISSUES AND METHOD OF ITS USE | 2012 |
|
RU2522778C2 |
| AGENT PROMOTING THERAPEUTIC ANGIOGENESIS AND METHOD FOR IMPLEMENTATION THEREOF | 2009 |
|
RU2449799C2 |
| METHOD OF ANGIOGENESIS AUGMENTATION IN ISCHEMIC TISSUES AND COMBINATION DRUG FOR METHOD IMPLEMENTATION | 2015 |
|
RU2628706C2 |
| OPTIMIZED NUCLEOTIDE SEQUENCE AND PHARMACEUTICAL COMPOSITIONS BASED THEREON WITH SUSTAINED VEGF TRANSGENE EXPRESSION | 2015 |
|
RU2612497C2 |
| TREATING AND PREVENTING CARDIAC DISEASES WITH USING TWO OR MORE ISOFORMS OF HEPATOCYTE GROWTH FACTOR | 2009 |
|
RU2448159C1 |
| CODON-OPTIMISED SEQUENCES AND PHARMACEUTICAL COMPOSITION FOR RECOVERY OF BLOOD VESSELS | 2014 |
|
RU2557385C1 |
| METHOD FOR THERAPY OF SKIN DAMAGES AND BIOTRANSPLANT THEREFOR | 2014 |
|
RU2588835C1 |
| VEGF BINDING V9 NANOANTIBODY AND METHOD OF OBTAINING SAID ANTIBODY, V9-CODING NUCLEOTIDE SEQUENCE AND VECTOR CONTAINING SAID SEQUENCE, ENDOTHELIAL CELL PROLIFERATION INHIBITION METHOD | 2008 |
|
RU2395521C1 |
| METHOD FOR TREATING DIABETIC FOOT SYNDROME BEFORE FORMATION OF ULCEROUS DEFECT USING EXTRACORPORAL SHOCK WAVE THERAPY | 2016 |
|
RU2632683C1 |
