METHOD OF PRODUCING COORDINATION COMPOUNDS OF OLIGOGALACTURONIC ACID WITH BIOGENIC METALS (II) AS DELIVERY SYSTEMS OF BIOGENIC METALS (II) AND SYSTEMS FOR REMOVING HEAVY METALS (II) Russian patent published in 2016 - IPC A61K31/732 C08B37/06 C07H23/00 A61P39/00 

FIELD: medicine.

SUBSTANCE: invention relates to pharmacology, and describes a method of producing coordination compounds of oligogalacturonic acid with biogenic metals (II). Method involves production of pectin-containing preparation of oligogalacturonic acid with polymerisation degree equal to no less than 10, subjected to reaction with metal salt (II): copper, cobalt, iron, zinc, manganese, magnesium in aqueous medium at neutral pH, exposing reaction mixture at room temperature, neutralisation of formed acid, water flushing, centrifugation and drying precipitate. According to invention to 1 l of 5.0·10^-3 M aqueous solution of purified oligogalacturonic acid while stirring is added first 2 M aqueous solution of ammonia hydrate to pH 8, then 1 l of 4.5·10^-2 M aqueous solution of metal acetate (II); formed gel-like precipitate is treated with 96 % ethanol at volume ratio of 1:2, held for 2 hours.

EFFECT: invention ensures delivery of biogenic metals (II), as well as removal of heavy metal cations (II) from body.

1 cl, 8 tbl, 4 dwg, 6 ex