FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology and immunology. Antibodies are described, which specifically bind with P-selectin, block binding of PSGL-1 with P-selectin and cause dissociation of previously formed complexes of P-selectin/PSGL-1. Previously unknown binding domain of antibody near N-end (conformational epitope) of P-selectin is described, which antibodies bind. Disclosed antibodies bind with conformational epitope of P-selectin and have double blocking function, consisting in binding of PSGL-1 with P-selectin and dissociation of previously formed complexes of P-selectin/PSGL-1. This double function of P-selectin antibodies and their binding fragments can be used in treating various acute and chronic inflammatory and thrombotic diseases and states.
EFFECT: proposed invention can be used in medicine.
14 cl, 7 dwg, 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| ANTIBODIES | 2005 |
|
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| ANTI-PSGL-1-ANTIBODIES AND THEIR APPLICATION | 2012 |
|
RU2650817C2 |
| TETRAVALENT ANTIBODIES TO PSGL-1 AND THEIR APPLICATIONS | 2017 |
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| P-SELECTIN GLYCOPROTEIN LIGAND 1 MODULATORS | 2004 |
|
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| ANTI-IGF-1R ANTIBODY AND USE THEREOF AS AN ADDRESS VECTOR FOR CANCER TREATMENT | 2015 |
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| METHOD OF TREATING INFLAMMATORY PAIN | 2009 |
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| ANTI-HEPCIDIN ANTIBODIES AND USES THEREOF | 2014 |
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| METHODS OF TREATING CHRONIC PAIN | 2009 |
|
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| ANTI-SEZ6 ANTIBODIES AND METHODS FOR USING THEM | 2013 |
|
RU2691698C2 |
| RECOMBINANT ANTIBODY IL4 USED FOR TREATMENT OF DISORDERS ASSOCIATED WITH FUNCTION OF IL4 | 1994 |
|
RU2162711C2 |
