3-CARBOXY-4-AMINOQUINOLINE DERIVATES, USEFUL AS SWEET TASTE MODIFIERS Russian patent published in 2016 - IPC C07D215/42 C07D403/12 C07D405/12 A61K31/4706 A61K31/4709 A61K31/4427 A23L2/60 A23L27/30 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to novel quinoline derivatives of general formula (IIIb) or ingestible salt thereof, where A is NH₂; B is C₁-C₄ alkyl; C is -CO₂R⁷; R⁷ is hydrogen; L¹ is C₁-C₈ alkylene, C₆-cycloalkylene or -CH₂-C₆-cycloalkylene; L² is -O-, NR³⁴-C(O)-, -C(O)-NR³⁴-, -(3-6-member heterocyclylene-C(O))-group, where heterocyclylene contains one nitrogen atom; R³³ is C₁-C₆ alkyl, optionally substituted C₁-C₆ alkoxy or hydroxy, C₃-C₁₀ carbocyclyl, optionally substituted with one C₁-C₆ alkoxy, C₆-C₁₀ aryl, optionally substituted with one or two substitutes, selected from -OH, halogen, -C(=O)NH₂, -C(=O)NHC_1-6 alkyl, C₁-C₆ alkoxy, C₁-C₆ alkyl-OH and O-C₁-C₆ alkyl-OH, C₆-C₁₀ aryl C₁-C₄ alkyl, optionally substituted C₁-C₆ alkoxy, 5-10-member heterocyclyl containing 1 or 2 oxygen atoms, pyridine or pyridine-C₁-C₄ alkyl; and R³⁴ is hydrogen. Invention also relates to quinoline derivatives of formula (IIIc) and (IIIc'), specific quinoline derivatives, ingestible composition based on compounds of formula (IIIb), (IIIc) and (IIIc'), method of enhancing sweet taste of ingestible composition, method of producing intermediate compounds of formulae (IV) and (IVc).

EFFECT: novel quinoline derivatives, useful as sweet taste modifiers.

23 cl, 23 tbl, 133 ex

, , ,