FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing 1-[2-(2,4-dimethyl-phenylsulphanyl)phenyl]piperazine or its pharmaceutically acceptable salts 
, 
, 
, 
wherein method involves reaction of a compound of formula II, where X denotes Br or I, with a compound of formula III, where Y is Cl or Br, and R' is hydrogen or a metal ion, and a compound of formula IV, where R is hydrogen or a protective group, in presence of a solvent, base and a palladium catalyst, consisting of a source of palladium and phosphine ligands, at temperature from 50 to 130 C.
EFFECT: technical result is a novel method of producing 1-[2-(2,4-dimethyl-phenylsulphanyl) phenyl] piperazine derivatives with high output and purity, which makes it possible to avoid or reduce formation of impurities.
18 cl, 2 tbl, 4 ex
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