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2 614 142

(13)

(51)

IPC

C07C211/29(2006-01-01)

C07C209/50(2006-01-01)

(21) (22)

Application

2016101021, 2016-01-14

(24)

Start date

2016-01-14

(22)

Actual filing date

2016-01-14

(45)

Published

2017-03-23

(72)

Inventor

Shtrykova Viktoriya ViktorovnaKuksenok Vera YurevnaFilimonov Viktor Dmitrievich

(73)

Holder

Federalnoe Gosudarstvennoe Avtonomnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Issledovatelskij Tomskij Politekhnicheskij Universitet"

METHOD FOR PRODUCTION OF META-CHLOROBENZHYDRYLAMINE - SEMI-PRODUCT IN SYNTHESIS OF ANTICONVULSANT PREPARATION GALODIF Russian patent published in 2017 - IPC C07C211/29 C07C209/50

Abstract RU 2614142 C1

FIELD: chemistry.

SUBSTANCE: invention relates to an improved method of production of meta-chlorobenzhydrylamine using Ritter reaction of meta-chlorobenzophenone. Obtained compound is an intermediate product and can be used for production of known anticonvulsant "galodif". Method for production of meta-chlorobenzhydrylamine comprises reduction of meta-chlorobenzophenone with NaBH₄ in a medium of ethyl alcohol to produce meta-chlorobenzhydrol, which is reacted with acetonitrile in presence of sulphuric acid at 60 °C. Or reduction of meta-chlorobenzophenone with NaBH₄ is carried out in a medium of acetonitrile, with subsequent addition of sulphuric acid. Obtained reaction mass is neutralised and meta-chlorobenzhydrylacetamide, which is treated with concentrated hydrochloric acid in isopropyl alcohol (IPA) and reaction mass is neutralised with 30 % aqueous sodium hydroxide solution with separation of end product.

EFFECT: method enables to reduce temperature and process duration and obtain a product with high output.

1 cl, 2 ex

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RU 2 614 142 C1

Authors

Shtrykova Viktoriya Viktorovna

Kuksenok Vera Yurevna

Filimonov Viktor Dmitrievich

Dates

2017-03-23—Published

2016-01-14—Filed