METHOD OF OBTAINING SUBSTITUTED AMINOBENZHYDROLS Russian patent published in 2009 - IPC C07C209/36 C07C217/76 C07C215/68 C07D295/33 

FIELD: chemistry.

SUBSTANCE: invention relates to method of obtaining substituted aminobenzhydrols, which can be used as semi-products in synthesis of medications of general formula , where: R₁=R₃=H, R₂=NH₂, R₄=Cl (1); R₁=R₃=H, R₂=NH₂, R₄=Br (2); R₁=R₃=H, R₂=NH₂, R₄=OCH₃ (3); R₁=R₄=H, R₂=NH₂, R₃=Cl (4); R₁=H, R₂=NH₂, R₃=Cl, R4=Cl (5); R₁=NH₂, R₂=Cl, R₃=R₄=H (6); R₁=NH₂, , R₃=R₄=H (7); R₁=NH₂, R₂=Cl, R₃=H, R₄=Cl (8); R₁=NH₂, , R₃=H, R₄=Cl (9); R₁=NH₂, R₃=Cl, R₂=R₄=H (10); R₁=NH₂, , R₂=R₄=H (11); R₁=NH₂, R₂=H, R₃=Cl, R₄=Cl (12); R₁=NH₂, R₂=H, , R₄=Cl (13), whish lies in simultaneous reduction of nitro- and carbonyl groups of respective nitrobenzphenones of general formula , where: R₁=R₃=H, R₂=NO₂, R₄=Cl; R₁=R₃=H, R₂=NO₂, R₄=Br; R₁=R₃=H, R₂=NO₂, R₄=OCH₃; R₁=R₄=H, R₂=NO₂, R₃=Cl; R₁=H, R₂=NO₂, R₃=Cl, R₄=Cl; R,=NO₂, R₂=Cl, R₃=R₄=H; R₁=NO₂, , R₃=R₄=H; R₁=NO₂, R₂=Cl, R₃=H, R₄=Cl; R₁=NO₂, , R₃=H, R₄=Cl; R₁=NO₂, R₃=Cl, R₂=R₄=H; R₁=NO₂, , R₂=R₄=H; R₁=NO₂, R₂=H, R₃=Cl, R₄=Cl; R₁=NO₂, R₂=H, , R₄=Cl, reducing system Zn-NaBH₄ in alcohol with molar ratio of substratum : zinc: sodium tetrahydroborate equal 1 : 3.5 : 0.25.

EFFECT: reduction of synthesis cost, reduction of time and temperature for process carrying out, increase of target products output.

1 cl, 2 tbl, 13 ex