FIELD: pharmacology.
SUBSTANCE: invention relates to a method for a glibenclamide drug in asolution form for injection in ampoules, characterized by 2-hydroxypropyl-β-cyclodextrin diluted in preheated water for injection, glibenclamide addition and stirring until complete dissolution, the resulting solution is allowed to stand for 35-40 minutes, cooled to 18-30°C, then sterilized by filtration through membrane filters with pore size of 0.22-0.3 mm, poured into ampoules of neutral glass, sealed and sterilized at 120°C for 8-15 minutes, at that, the components are used in amounts providing osmolality within 239-376 mOsm/l.
EFFECT: invention implementation provides a stable injectable formulation of glibenclamide with high bioavailability.
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