AGENT FOR REDUCTION OF GLUTAMATE-INDUCED APOPTOSIS AND INHIBITION OF NMDA-RECEPTOR, POSSESSING IMMUNOMODULATORY ACTION, FOR TREATING NERVOUS SYSTEM DISORDERS, EFFECTS OF CRANIOCEREBERAL INJURY AND ISCHEMIC AND HEMORRHAGIC STROKE Russian patent published in 2016 - IPC A61K31/7068 A61K31/13 A61K47/48 A61P9/10 A61P25/00 

Abstract RU 2605339 C2

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to medicine and pharmaceutical industry and represents therapeutic agent, based on amantadine sulphate, for reduction of glutamate-induced apoptosis and inhibition of NMDA-receptors for treating nervous system disorders, effects of craniocereberal injury and ischemic and hemorrhagic stroke, characterized by that it contains therapeutically effective amount of amantadine sulphate and cytidine 5'-diphosphocholine as active substance, as well as at least one auxiliary substance, selected from group consisting of stabilizers, prolongators, buffering additive solvents, fillers, preserving agents, ingredients are taken in certain ratio, wt%.

EFFECT: invention provides extending of range of products for reduction of glutamate-induced apoptosis and inhibition of NMDA-receptors for treating disorders of nervous system, effects of craniocereberal injury and ischemic and hemorrhagic stroke, increase of clinical effectiveness, stability at room temperature, long storage life, at least 3 years.

4 cl, 3 ex, 3 tbl

Similar patents RU2605339C2

Title Year Author Number
INJECTION DOSAGE FORM FOR TREATING ACUTE ISCHEMIC STROKE AND CRANIOCEREBERAL INJURY, METHOD FOR PREPARING AND USING 2009
  • Granstrem Oleg Konstantinovich
  • Nikitina Irina Valer'Evna
  • Rodionov Petr Petrovich
RU2431496C2
MEDICATION, PROVIDING NEURO-PROTECTIVE ACTION IN ACUTE PERIOD OF CRANIOCEREBRAL INJURY 2009
  • Belozertsev Feliks Jur'Evich
  • Juntsev Sergej Vasil'Evich
  • Belozertsev Jurij Alekseevich
  • Zapol'Skaja Julija Anatol'Evna
RU2414901C2
MEDICINAL AGENT OFFERING ANTI-ISCHEMIC, ANTIHYPOXIC AND ANTICONVULSANT EFFECT IN CRANIAL TRAUMA 2005
  • Belozertsev Feliks Jur'Evich
  • Belozertsev Aleksej Jur'Evich
  • Belozertsev Jurij Alekseevich
RU2309745C2
MEDICATION FOR TREATING CEREBRAL CIRCULATION DISORDERS AND BRAIN TRAUMAS 2012
  • Krajneva Valentina Aleksandrovna
  • Valdman Elena Arturovna
  • Kotelnikova Svetlana Olegovna
  • Maslennikov Denis Vadimovich
  • Ganshina Tamara Sergeevna
  • Gnezdilova Anna Viktorovna
  • Mirzoyan Ruben Simonovich
  • Voronina Tatyana Aleksandrovna
  • Ivanova Elena Anatolevna
  • Kokshenev Igor Igorevich
RU2554502C9
MEDICINAL AGENT SHOWING MULTIFACTOR NEUROPROTECTIVE AND NOOTROPIC EFFECT IN CRANIAL TRAUMA 2005
  • Belozertsev Feliks Jur'Evich
  • Belozertsev Aleksej Jur'Evich
  • Belozertsev Jurij Alekseevich
  • Shirshov Jurij Aleksandrovich
RU2318501C2
PHARMACEUTICAL COMPOSITION FOR TREATING CONSEQUENCES OF CRANIOCEREBRAL INJURY AND METHOD FOR PRODUCTION THEREOF (EMBODIMENTS) 2018
  • Narkevich Igor Anatolevich
  • Teslev Andrej Aleksandrovich
  • Okovityj Sergej Vladimirovich
  • Ivkin Dmitrij Yurevich
  • Bolotova Vera Tsezarevna
  • Sysoev Yurij Igorevich
  • Terenteva Oksana Andreevna
  • Titovich Irina Aleksandrovna
  • Flisyuk Elena Vladimirovna
RU2693633C1
MEDICATION PRODUCING ANTI-ISCHEMIC, ANTIHYPOXIC AND ANTIAMNESTIC ACTION IN ACUTE PERIODE OF CRANIOCEREBRAL TRAUMA 2009
  • Belozertsev Feliks Jur'Evich
  • Juntsev Sergej Vasil'Evich
  • Belozertsev Jurij Alekseevich
  • Shchelkanova Ol'Ga Aleksandrovna
RU2424802C2
NEURORABILITATION AGENT BASED ON SODIUM 6-OXO-1-PHENYL-2-(PHENYLAMINO)-1,6-DIHYDROPYRIMIDINE-4-OLATE 2018
  • Sysoev Yurij Igorevich
  • Okovityj Sergej Vladimirovich
  • Anisimova Natalya Askoldovna
  • Yakovlev Igor Pavlovich
  • Chernov Nikita Maksimovich
RU2675694C1
APPLICATION OF BETA-HYDROXYBUTYRATE OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS FOR PREPARATION OF MEDICATION WHICH POSSESSES CYTOPROTECTIVE ACTIVITY, INCLUDING NEUROPROTECTIVE, CARDIOPROTECTIVE, ANTI-ISCHEMIC, ANTI-HYPOXIC, ANTI-STRESS, ACTOPROTECTIVE AND ADAPTOGENIC ACTIVITY, MEDICATION AND METHOD OF PREVENTION, RELIEF AND TREATMENT BY MEANS OF SAID MEDICATION 2009
  • Morozova Margarita Alekseevna
  • Beniashvili Allan Gerovich
  • Brusov Oleg Sergeevich
  • Zapol'Skij Maksim Ehduardovich
  • Ehdiger Aleksandr Vladimirovich
  • Fazylov Marat Feliksovich
  • Nesteruk Vladimir Viktorovich
RU2426535C2
METHOD OF TREATING ISCHEMIC STROKE 2013
  • Medvedev Oleg Stefanovich
  • Kalenikova Elena Igorevna
  • Gorodetskaja Evgenija Aronovna
  • Belousova Margarita Alekseevna
  • Povarova Oksana Viktorovna
RU2554500C2

RU 2 605 339 C2

Authors

Khoroshilova Galina Vladimirovna

Koverda Mikhail Nikolaevich

Zemljanukhina Ekaterina Sergeevna

Dates

2016-12-20Published

2013-07-23Filed