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(19)

(11)

2 620 068

(13)

(51)

IPC

C07K16/40(2006-01-01)

A61K39/395(2006-01-01)

A61K45/06(2006-01-01)

C07K16/18(2006-01-01)

(21) (22)

Application

2014120757, 2012-11-20

(24)

Start date

2012-11-20

(22)

Actual filing date

2012-11-20

(45)

Published

2017-05-22

(72)

Inventor

Chovdkhuri Partkha S.Tajs DevidSyao ChzhanStejner FilippKinnir KristaRebelatto Marlon

(73)

Holder

Medimmyun, Elelsi

BINDING MOLECULE SPECIFIC FOR HER3, AND THEIR APPLICATIONS Russian patent published in 2017 - IPC C07K16/40 A61K39/395 A61K45/06 C07K16/18

Abstract RU 2620068 C2

FIELD: chemistry.

SUBSTANCE: antibodies and antigen binding fragments thereof are described, that bind an extracellular domain of HER3 receptor and inhibit various functions associated with HER3 receptor by means of a ligand-dependent and/or ligand-independent mechanism. The compositions with increased half-life are represented as well. Furthermore, invention relates to compositions and methods for diagnosis and treatment of diseases associated with HER3-mediated signal transduction.

EFFECT: invention expands the arsenal of diagnostic tools and treatment of diseases associated with HER3-mediated signal transduction.

23 cl, 37 dwg, 7 tbl, 4 ex

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RU 2 620 068 C2

Authors

Chovdkhuri Partkha S.

Tajs Devid

Syao Chzhan

Stejner Filipp

Kinnir Krista

Rebelatto Marlon

Dates

2017-05-22—Published

2012-11-20—Filed