FIELD: pharmacology.
SUBSTANCE: invention relates to novel quinazoline-4(3H)-one derivatives of the general formula (I) which possess neuroprotective and cardioprotective activity and can be widely used in treatment of diseases of the central nervous and cardiovascular system of vascular, traumatic, toxic and hypoxic origin. In formula (I)
, (I)
R1 = H or CH3; R2 = H, Cl or Br; R3 = H or Br; R4 = H or CH3. On experimental models in vivo, the compounds of formula (I), having the ability to protect the brain and myocardium under the conditions of circulatory insufficiency, surpass the drugs of various pharmacological groups, such as verapamil, ivabradine, cavinton, mexidol, piracetam, in a range of useful properties.
EFFECT: increased efficiency of treatment.
13 tbl, 4 ex
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