FIELD: pharmacology.
SUBSTANCE: invention is a pharmaceutical composition in the form of a pille dispersed in the mouth, containing: 2.0 to 15.0 wt % of memantine; 1.0 to 10.0 wt % of melatonin; 65.0 to 80.0 wt % of the filler selected from mannitol or mannitol mixture with copovidone; 4.0 to 15.0 wt % of desintegrant, selected from crospovidone; 1.0 to 2.0 wt % of the binding substance, selected from sorbitol; 1.0 to 2.5 wt % of the sweetener selected from maltitol, sodium saccharinate, or a mixture thereof; 0.5 to 1.0 wt % of the sliding substance selected from colloidal silicon dioxide, stearic acid, magnesium stearate, talc or mixtures thereof; 1.5 to 3.0 wt % of flavor, as well as a production method.
EFFECT: expansion of the arsenal of pharmaceutical compositions containing a combination of memantine and melatonin, increased storage stability and dissolution rate.
12 cl, 6 ex
