PHARMACEUTICAL COMPOSITION CONTAINING THE COMBINATION OF MEMANTINE AND MELATONIN Russian patent published in 2018 - IPC A61K31/13 A61K31/4045 A61K9/20 A61P25/28 A61K47/26 A61K47/38 

FIELD: chemical-pharmaceutical industry.

SUBSTANCE: invention relates to the chemical-pharmaceutical industry and is a pharmaceutical composition in the form of a tablet dispersible in the oral cavity for the prevention and treatment of mental, behavioral, cognitive disorders, that contains memantine, melatonin, a filler comprising a mixture of mannitol and copovidone, a disintegrant, comprising at least one component selected from sodium carboxymethyl cellulose, croscarmellose, a binder comprising at least one component selected from sorbitol, cellulose derivatives, polyethylene glycols, sodium alginate, a sweetener comprising at least one component selected from maltitol, sodium saccharinate or mixtures thereof, a lubricant selected from colloidal silicon dioxide, stearic acid, magnesium stearate or mixtures thereof, a flavoring agent.

EFFECT: invention makes it possible to increase the safety, storage stability and dissolution rate of a pharmaceutical composition comprising a combination of memantine and melatonin.

4 cl, 7 ex, 16 tbl