FIELD: pharmacology.
SUBSTANCE: group of inventions concerns low-viscosity hypotonic pharmaceutical compositions containing a concentrated PRO 140 monoclonal antibody in an amount of 100 to 200 mg/ml, a tonicity regulator in the form of a salt selected from sodium chloride, sodium gluconate or sodium lactate in an amount of 90 to 95 mM, and a buffer solution. They are used in pharmaceutical compositions and finished products.
EFFECT: possibility of subcutaneous administration or delivery of a high concentration of a protein drug, such as PRO 140 monoclonal antibody, to a subject suffering from a disease or condition that can be cured with the said protein drug.
81 cl, 7 ex, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| STABLE AQUEOUS COMPOSITIONS OF PROTEIN MIA/CD-RAP | 2011 |
|
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| COMPOSITION CONTAINING ANTIBODY | 2019 |
|
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|
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|
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|
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|
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| COMPOSITION CONTAINING HIGHLY CONCENTRATED ALPHA-1-PROTEINASE INHIBITOR AND METHOD OF ITS PREPARATION | 2019 |
|
RU2813136C1 |
| LIQUID PROTEIN FORMULATIONS CONTAINING IONIC LIQUIDS | 2014 |
|
RU2675824C2 |
